Synergism between Mimusops Elengi and Bauhinia Variegata Seed Extracts against Salmonella Enterica Serovar Typhi and Vibrio Cholerae O1 Biotype El Tor Serotype Ogawa Isolates

The current communication evaluates the antibacterial activity of Mimusops elengi (M. elengi) and Bauhinia variegata (B. variegata) seed extracts, alone and in combination, against Salmonella enterica serovar Typhi (S. typhi) and Vibrio cholerae O1 biotype El Tor serotype Ogawa (V. cholerae) isolates. The antibacterial activity of ethanolic extracts of bakul, M. elengi, seed (MSE; 500 μg) and kanchan, B. variegata, seed (BSE; 500 μg), alone and in combination, was determined following agar diffusion method, for a total of 16 S. typhi and V. cholerae isolates. The zone diameter of inhibition (ZDI) for the agents was recorded, and growth inhibitory indices (GIIs) were calculated. The V. cholerae and S. Typhi isolates had BSE (500 μg) and MSE (500 μg) ZDIs 12-17 mm and 13-15 mm, respectively. The GIIs of the BSE-MSE combination ranged 0.654 0.788 and 0.538 0.759 for the isolates of S. typhi and V. cholerae, respectively. The combined activity of BSE and MSE was synergistic against the test bacterial isolates, and the test plant extracts are potential in combating S. typhi and V. cholerae drug resistance and hence are important sources for the development of non-antibiotic drug(s) against S. typhi and V. cholerae infection.